Author: B. Krupa Karuna Vani
Abstract: Simple, fast and reliable UV and derivative Spectrophotometric methods were developed for determination of Canagliflozin in pharmaceutical formulation. Canagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for treatment of type 2 diabetes mellitus. Absorption for NH was measured at maximum wavelength 227nm. Analytical Calibration curves were linear within a concentration range from 2-12μg/ml. The developed method was applied to directly and easily to the analysis of the pharmaceutical tablet preparations. The percentage recovery of Canagliflozin in pharmaceutical dosage form was found to be 98.57-100.75% for UV, 98.50-99.880% for first derivative and 98.87-99.90% for second derivative methods respectively. The method was completely validated and proven to be rugged. The results obtained were statistically evaluated and were found to be accurate and reproducible. The excipients did not interfere in the analysis. The results showed that this method can be used for rapid determination of Canagliflozin in pharmaceutical tablet.